USC Stevens Neuroimaging and Informatics Institute
USC Stevens Neuroimaging and Informatics Institute
  • 78
  • 638 892
Tracking arterial blood as it moves through the brain's capillaries
In the animated video, we employ arterial spin labeling (ASL) to label and track arterial blood as it moves through the brain's capillaries. This technique allows us to visualize the exchange of labeled water molecules through the blood-brain barrier (BBB) into the brain tissue, a process facilitated by various transport mechanisms, including aquaporin 4 (AQP4) channels. The video illustrates that water molecules travel more rapidly within the vessels and slow down in the tissue due to the dense interstitial space. By applying a slight diffusion weighting, we can selectively null the signal from the faster-moving water in the capillaries. Leveraging this principle, our diffusion-prepared ASL MRI technique differentiates signals from within the vessels and tissues, enabling us to measure the water exchange rate across the BBB, known as 'kw'.
Here are examples acquired from in vivo data at two time points. The upper left images display the perfusion signal, while the lower left images showcase the capillary signal. These images show distinct patterns over time, shedding light on the intricacies of blood flow and water exchange through the BBB. Utilizing this data, we can compute a comprehensive cerebral blood flow (CBF) and kw map (right) for the entire brain by employing mathematical modeling techniques.
Переглядів: 308

Відео

Locus Coeruleus pathways to Transentorhinal Cortex
Переглядів 5463 місяці тому
A probabilistic atlas of Locus Coeruleus pathways to Transentorhinal cortex for connectome imaging in Alzheimer's disease Produced by: Jim Stanis, Yonggang Shi, Xinyu Nie and Arthur W. Toga at the Laboratory of Neuro Imaging Dataset provided by John Ringman. LONI is a part of the Mark and Mary Stevens Neuroimaging and Informatics Institute at The University of Southern California Wei Sun, Yuchu...
T1 brain with tumor perfusion volume
Переглядів 3074 місяці тому
High resolution isotropic 2mm cerebral blood flow map of a grade IV Glioblastoma (GBM) using arterial spin labeling at 7 Tesla, heterogeneous perfusion can be seen within the tumor with high flow indicating aggressively growing parts of the GBM
Cone photoreceptors in rat retina
Переглядів 3245 місяців тому
Photoreceptor cells (blue) in the retina of the eye transduce light waves into sensory neural signals for vision. Cone photoreceptor cells (green) are especially sensitive to different light wavelengths within their cone-shaped outer segment and allow us to perceive colors as a mixture of reds, greens, and blues.
Black blood small vessels
Переглядів 3276 місяців тому
This video shows 3D rendering of small cerebral blood vessels on the order of a few hundred microns visualized and segmented on 3D high-resolution black blood MRI with isotropic 0.5mm resolution acquired at clinical magnetic field strength of 3 Tesla. Black blood contrast is caused by suppressing the blood signal, which is extremely useful to visualize the vessel wall or for the characterizatio...
mouse hippocampus neurons
Переглядів 1,2 тис.Рік тому
mouse hippocampus neurons
Mouse hippocampus volume cropped, large dataset 2048 ROI, clipping animation
Переглядів 372Рік тому
Mouse hippocampus volume cropped, large dataset 2048 ROI, clipping animation
T1 MRI data with hippocampus and vasculature
Переглядів 512Рік тому
T1 MRI data with hippocampus and vasculature
HABS T1 MR Amyloid Tau negative/positive comparison with Hippocampal atrophy
Переглядів 337Рік тому
HABS T1 MR Amyloid Tau negative/positive comparison with Hippocampal atrophy
IDA Uploader 2.0 Tutorial
Переглядів 318Рік тому
The tutorial shows how to use the IDA Uploader to safely de-identify and upload image data to the LONI IDA. For additional resources, visit our support page at ida.loni.usc.edu/explore/jsp/support/support.jsp Tags: #IDA #IDAUploader
AI and machine learning for Neuroimaging at the INI
Переглядів 1,1 тис.2 роки тому
Here at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) we are working to develop, validate and disseminate artificial intelligence (AI) methods and techniques to improve the diagnosis and treatment of brain diseases, identify biological markers of aging and neurodegeneration, and improve the accuracy of clinical imaging, among other challenges. Check out our ...
Imaris very large field V4
Переглядів 3632 роки тому
Imaris very large field V4
Ultrahigh Field MRI - The Value of Fine-Grained Examination
Переглядів 7 тис.2 роки тому
Ultrahigh field MRI with field strengths at or above 7 Tesla, allows neuroscientists to collect detailed images of very small structures in the brain, such as subfields of the hippocampus, a key structure damaged in aging and neurodegenerative diseases. Ultrahigh field MRI also offers increased resolution and contrast for studying blood vessels in the brain from large arteries to very small len...
cube of cubes
Переглядів 4172 роки тому
cube of cubes
Inner Brain with Lenticulostriate arteries - collected from 7T data
Переглядів 3263 роки тому
This visualization depicts lenticulostriate arteries (LSAs), which are very small blood vessels in the brain. The data was collected by a ultra-high field 7Tesla MRI scanner. Visualizing these vessels using non-invasive MRI scans can help advance the study and treatment of cerebral small vessel disease.
3D 7T Perfusion fMRI
Переглядів 5843 роки тому
3D 7T Perfusion fMRI
Comparison between finger tapping (FT) and finger brushing (FB) evoked perfusion activation, 7T fMRI
Переглядів 4393 роки тому
Comparison between finger tapping (FT) and finger brushing (FB) evoked perfusion activation, 7T fMRI
Inner Brain, with Lenticulostriate artery branches
Переглядів 7463 роки тому
Inner Brain, with Lenticulostriate artery branches
Averaged hippocampal subfields
Переглядів 6 тис.3 роки тому
Averaged hippocampal subfields
Evolutionary change in hippocampus and brain structure shown from human back to mouse.
Переглядів 2,8 тис.3 роки тому
Evolutionary change in hippocampus and brain structure shown from human back to mouse.
Normal and Alzheimer's brains dataset comparison.
Переглядів 18 тис.3 роки тому
Normal and Alzheimer's brains dataset comparison.
THC Exposure is Reflected in the Microstructure of the Cerebral Cortex and Amygdala of Young Adults
Переглядів 8444 роки тому
THC Exposure is Reflected in the Microstructure of the Cerebral Cortex and Amygdala of Young Adults
Variation in tractography-derived measures in corticospinal tract reconstruction.
Переглядів 1,9 тис.4 роки тому
Variation in tractography-derived measures in corticospinal tract reconstruction.
COVID-19 Data Archive (COVID-ARC)
Переглядів 5824 роки тому
COVID-19 Data Archive (COVID-ARC)
A probabilistic atlas of human brainstem pathways based on connectome imaging data
Переглядів 1,6 тис.4 роки тому
A probabilistic atlas of human brainstem pathways based on connectome imaging data
Human Connectome Diffusion tractography
Переглядів 1,1 тис.4 роки тому
Human Connectome Diffusion tractography
Schol-AR
Переглядів 3,8 тис.4 роки тому
Schol-AR
Perivascular spaces
Переглядів 7 тис.4 роки тому
Perivascular spaces
James Stanis INI USC - NIH Brain initiative 2019 submission
Переглядів 12 тис.4 роки тому
James Stanis INI USC - NIH Brain initiative 2019 submission
Human Connectome Project - diffusion imaging
Переглядів 2 тис.5 років тому
Human Connectome Project - diffusion imaging

КОМЕНТАРІ

  • @prinzessor
    @prinzessor 4 місяці тому

    Some help will be appreciated (as marked with ??? ) : "Diffusion imaging can be represented by different mathematical quantities. One such quantity ist the principle diffusion direction or PDD. The PDD indicates the direction, where the greatest diffusion occurs. Color clues in the viewer (???), as to which way the white matter pathways curve. Anterior posterior paths are green, superior to inferior paths are blue, and left to right paths are red. A combination of directions creates tratcs, colored orange and yellow. A different combination creates purple. And a final combination creates aqua. A few large fiber bundels, like the corpus callosum, the visual pathway and the ??? bundles and the corona radiata and cortical spinal tract are easy to spot, as they predominantly lie along the X Y or Z axis. The tractography along the principal diffusion direction the brains connections can be fully mapped."

  • @four-en-tee
    @four-en-tee 4 місяці тому

    my brain when it sees cringe

  • @thanhduyentu1519
    @thanhduyentu1519 8 місяців тому

    It's so great. I recently cure my illness already. My schizophrenia had cured. Thank you world.

  • @xtremeyoylecake
    @xtremeyoylecake 9 місяців тому

    It reminds me of the nematodes from SpongeBob, eating the Pineapple house…I feel so bad for people suffering from Alzheimer’s:(

  • @rounakbhattacharyya1658
    @rounakbhattacharyya1658 Рік тому

    Please give me some data

  • @fainazahamed
    @fainazahamed Рік тому

    CAN YOU GIVE ME THOSE DATAS FOR FINAL YEAR PROJECT

  • @LifeAsANoun
    @LifeAsANoun Рік тому

    holy god... what? I really hope there's a way to re-do this without the "music" drowning out the voice.

  • @charles2675
    @charles2675 Рік тому

    White matter ??

  • @chrisnyhuis2733
    @chrisnyhuis2733 2 роки тому

    So that's what's happening to my dad's brain 😔😔

    • @D.Martyr
      @D.Martyr 10 місяців тому

      I'm so sorry you and you family has to go through this... I'm so sorry your dad's suffering

  • @benrifkahbergsten-buret8547
    @benrifkahbergsten-buret8547 3 роки тому

    Great music and sound effects but I can't hear the narration over them.

  • @benrifkahbergsten-buret8547
    @benrifkahbergsten-buret8547 3 роки тому

    I dig the music, but it's so loud that I'm distracted from the narration.

  • @user-ud3cv2wu5m
    @user-ud3cv2wu5m 3 роки тому

    Энцефалограмма.

  • @Trump_y_Gore_Won
    @Trump_y_Gore_Won 3 роки тому

    This is very interesting! Thank you.

  • @DarkMoonDroid
    @DarkMoonDroid 4 роки тому

    God, this is fucking awesome!!

  • @rezadarooei248
    @rezadarooei248 4 роки тому

    music sound is too high

  • @cytroyd
    @cytroyd 4 роки тому

    root of all the bs

  • @soranrikurin979
    @soranrikurin979 4 роки тому

    The music is very distracting. If you want audio you should have added a voice explaining the concept.

  • @russellnc
    @russellnc 4 роки тому

    the music is irritating and too much when talk is happening.

    • @DarkMoonDroid
      @DarkMoonDroid 4 роки тому

      I had to turn the volume way down so as not to disturb my neighbors.

  • @Adam-nr6ov
    @Adam-nr6ov 5 років тому

    0:15 seen as what ???? couldn't hear because of the annoying sound effects

  • @colourheists5587
    @colourheists5587 6 років тому

    my dog is playing the piano

  • @Vkep4eto
    @Vkep4eto 6 років тому

    Very nice presentation. However, what is up with the thumping sound track?

  • @pendagar449
    @pendagar449 6 років тому

    FINALLY FOUND WHERE MUSE GOT THEIR ALBUM COVER WOO

  • @asielsmith6007
    @asielsmith6007 7 років тому

    Is the colours for coding the directional diffusion, are used officially??

  • @infect1veprincess374
    @infect1veprincess374 7 років тому

    Can diffusion in our brain affect how we think and act? Can not enough diffusion cause sanity to drop? And can too much make it difficult to think? Although I don't know if we can diffuse too much. just curious.

  • @Drug_Design_Nabrosov
    @Drug_Design_Nabrosov 7 років тому

    dopaminergics... ua-cam.com/video/_kv9_Kt-fmg/v-deo.html . ua-cam.com/video/7MPIeT1_4eg/v-deo.html . ua-cam.com/video/lMUHS6m_Vxo/v-deo.html .

  • @aaronpsamuel
    @aaronpsamuel 8 років тому

    very informative, agree the sound FX are too high, they flood out the audio.

  • @EyewireOrg
    @EyewireOrg 9 років тому

    What is the viewer you are using here?

    • @MomsStuff10
      @MomsStuff10 9 років тому

      That is so incredible! I'd love to see my brain riddled w/MS.

  • @stephenmuth1425
    @stephenmuth1425 10 років тому

    Amazingly cool work your team is doing. A critique on your video production, though -- the whizzes, shizbangs and bingy-dingy-danga of the soundtrack swamps what is actually being said, esp. when the narrator swallows the occasional syllable. SFX and music tracks could be 20% of what they are, and it would work much better, esp. for those who might not understand the speech accent. (or who might be otherwise distracted by the flashes and visual gee-whiz) I'm not sure what this trend is with (particularly) American science video production, but the key should be clarity, not eye and ear candy for its own sake, IMHO.

  • @marhensa
    @marhensa 10 років тому

    MUSE

  • @juanmanueljuncocarrera5265
    @juanmanueljuncocarrera5265 10 років тому

    excelente GRACIAS